NOTE: The Ambulatory Care Drug Database made the switch to a Multum-based system of drug classification with the 2006 data year. As we work more with this system, we are identifying some issues which may affect data users. Specifically, in developing the new online drug database application, we discovered that Multum assigns certain drug characteristics differently than NCHS had done in the past. This was first noticed with aspirin, which Multum classifies as a prescription drug. The reason for this appears to be that there are certain strengths of aspirin that are only available by prescription, and Multum appears to code up to the highest level rather than differentiating prescription and non-prescription forms of drugs. This was also noticed with the DEA Status variable. Some drugs, such as codeine, may have multiple DEA statuses, depending on their dosage and route of administration. Multum codes such drugs up to their highest DEA status. Beginning with the 2008 drug data, we have worked with Multum to reclassify drugs within our own database to reflect multiple statuses. We wish to bring such issues to the attention of our data users so that they can be aware of any seeming contradictions with regard to these characteristics.
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MANILA — Department of the Interior and Local Government (DILG) Secretary Ismael D. Sueno has said that a pilot inter-agency community-based rehabilitation program for the care of drug surrenderers is set for soft launching this month.
Based on the recommendations of NDAC at its March 23, 2005, meeting, we are continuing to propose the use of bacterial log reductions as a means of demonstrating that health care antiseptics are GRAE (Ref. 8). The 1994 TFM also proposed final formulation testing for health care personnel hand washes (59 FR 31402 at 31448), surgical hand scrubs (59 FR 31402 at 31445), and patient preoperative skin preparations (59 FR 31402 at 31450). We do not discuss final formulation testing here because we are not proposing that any of the active ingredients are GRAS/GRAE. Although these proposed test methods are intended to evaluate the effectiveness of antiseptic final formulations, this type of clinical simulation testing when adequately controlled also can be used to demonstrate that an active ingredient is GRAE for use in a health care antiseptic product. Based on our experience with the approval of NDA antiseptic products and input from the March 2005 NDAC, we recommend that the bacterial log reduction studies used to demonstrate that an active ingredient is GRAE for use in health care antiseptic drug products include the following: